circRNA basic information
circBase ID: hsa_circ_0001777
Name: hsa_circ_ESYT2
Synonym: circ_0001777
Host Gene: hsa-miR-95-3p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: MCF10A, MDA-MB-231, MDA-MB-468
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: AKAP12
Associated microRNA: hsa-miR-95-3p
Biological function: inhibited cell proliferation, inhibited migration, inhibited invasion, promoted apoptosis
Molecular mechanism: -
Survival: better
Supported No.:
 1
Description:

Overexpression of circ_0001777 decreased proliferation, migration, and invasion of TNBC cells by regulating the miR-95-3p/AKAP12 axis, suggesting that circ_0001777/miR-95-3p/AKAP12 axis may be a potential regulatory mechanism for the treatment of TNBC.
Other information
Title:

Circ_0001777 Affects Triple-negative Breast Cancer Progression Through the miR-95-3p/AKAP12 Axis.

Journal: Clin Breast Cancer
Published: 2022/12/14
PubMed ID: 36513585