circRNA basic information
circBase ID: hsa_circ_0000173
Name: hsa_circ_ATP2B4
Synonym: circATP2B4
Host Gene: hsa-miR-532-3p
 
 
 
Disease basic information
DO ID:
 2394
DO name: ovarian cancer
Disease details: ovarian cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: A2780 cells
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: SREBF1
Associated microRNA: hsa-miR-532-3p
Biological function: promote epithelial ovarian cancer metastasis
Molecular mechanism: M2 macrophage polarization, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Collectively, these data indicate that circATP2B4-containing EVs generated by EOC cells promoted M2 macrophages polarization and malignant behaviors of EOC cells.
Other information
Title:

Extracellular Vesicle-Packaged circATP2B4 Mediates M2 Macrophage Polarization via miR-532-3p/SREBF1 Axis to Promote Epithelial Ovarian Cancer Metastasis.

Journal: Cancer Immunol Res
Published: 2022/12/14
PubMed ID: 36512324