circRNA basic information
circBase ID: -
Name: -
Synonym: CircCDR1as
Host Gene: -
 
 
 
Disease basic information
DO ID:
 1324
DO name: lung cancer
Disease details: lung cancer
Species: human
Species details: human
Sample type: cell line
Sample type details: H1299, A549 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SRSF1, VEGFA, PARK2
Associated microRNA: -
Biological function: the lower expression of circCDR1as impaired the growth size and metastatic ability of lung cancer cells in mouse tumour models
Molecular mechanism: Mechanistically, circCDR1as specifically bound to serine/arginine-rich splicing Factor 1 (SRSF1) and affected the splicing of vascular endothelial growth factor-A (VEGFA) by SRSF1. Furthermore, circCDR1as affected SRSF1 function by regulating PARK2-mediated SRSF1 ubiquitination, protein production and degradation. CircCDR1as also affected C-myc and cyclin D1 expression by regulating SRSF1 and affecting the wnt/beta-catenin signalling pathway, ultimately promoting malignant behavior and inhibiting the apoptosis of lung cancer cells, thereby causing PM2.5-induced lung cancer development.
Survival: -
Supported No.:
 1
Description:

CircCDR1as also affected C-myc and cyclin D1 expression by regulating SRSF1 and affecting the wnt/beta-catenin signalling pathway, ultimately promoting malignant behavior and inhibiting the apoptosis of lung cancer cells, thereby causing PM2.5-induced lung cancer development.
Other information
Title:

CircCDR1as mediates PM(2.5)-induced lung cancer progression by binding to SRSF1.

Journal: Ecotoxicol Environ Saf
Published: 2022/12/13
PubMed ID: 36508830