circRNA basic information
circBase ID: -
Name: ssc_circ_CREBBP
Synonym: circ-CREBBP
Host Gene: ssc-miR-10384, ssc-miR-143-3p
 
 
 
Disease basic information
DO ID:
 48
DO name: male reproductive system disease
Disease details: male reproductive diseases
Species: others
Species details: boar
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
DN
Associated gene: MCL1, CREBBP, CREB1
Associated microRNA: ssc-miR-10384, ssc-miR-143-3p
Biological function: These data suggested that low expression of circ-CREBBP in sperm leads to a significant decrease in sperm motility. These data showed that the number of apoptotic sperm significantly increased in the Si-circ-CREBBP group, indicating that circ-CREBBP inhibits sperm apoptosis. These results suggested that the levels of ATP in spermatozoa were markedly decreased in the Si-circ-CREBBP group, which further confirmed that the number of apoptotic sperm increased after the decrease in circ-CREBBP expression.
Molecular mechanism: circ-CREBBP/miR-10384/miR-143-3p/MCL1/CREBBP/CERB1 axis, miRNA sponge, PI3K-Akt signaling pathway
Survival: -
Supported No.:
 1
Description:

The above results suggested that circ-CREBBP indirectly regulated the expression of MCL1, CREBBP, and CERB1 through miR-10384 and miR-143-3p.
Other information
Title:

Circ-CREBBP inhibits sperm apoptosis via the PI3K-Akt signaling pathway by sponging miR-10384 and miR-143-3p.

Journal: Commun Biol
Published: 2022/12/9
PubMed ID: 36476986