circRNA basic information
circBase ID: -
Name: hsa_circ_CORO1C
Synonym: -
Host Gene: hsa-let-7c-5p
 
 
 
Disease basic information
DO ID:
 2876
DO name: laryngeal squamous cell carcinoma
Disease details: laryngeal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human LSCC cell line (FD-LSC-1), human LSCC cell line (TU-177), human cell lines (HEK293T, MRC-5)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: PBX3
Associated microRNA: hsa-let-7c-5p
Biological function: Knockdown of circCORO1C inhibited the proliferation, migration, invasion, and in vivo tumorigenesis of LSCC cells
Molecular mechanism: bound to let-7c-5p and prevented it from decreasing the level of PBX3
Survival: poor
Supported No.:
 2
Description:

Knockdown of circCORO1C inhibited the proliferation, migration, invasion, and in vivo tumorigenesis of LSCC cells. Mechanistic studies revealed that circCORO1C competitively bound to let-7c-5p and prevented it from decreasing the level of PBX3, which promoted the epithelial-mesenchymal transition and finally facilitated the malignant progression of LSCC.

Other information
Title:

Circular RNA circCORO1C promotes laryngeal squamous cell carcinoma progression by modulating the let-7c-5p/PBX3 axis.

Journal: Mol Cancer
Published: 2020/6/4
PubMed ID: 32487167