circRNA basic information
circBase ID: -
Name: hsa_circ_E-Cad
Synonym: Circ-E-Cad
Host Gene: -
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: GC cell lines (AGS, SGC-7901, KATO, MGC803, BGC823), a human gastric epithelial cell line (GES-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: cell proliferation, migration, and epithelial-mesenchymal transition
Molecular mechanism: -
Survival: -
Supported No.:
 1
Description:

TGF-beta/Smad pathway could increase the expression of C-E-Cad to regulate GC cell proliferation, migration, and epithelial-mesenchymal transition by affecting PI3K/AKT signaling.
Other information
Title:

Circ-E-Cad encodes a protein that promotes the proliferation and migration of gastric cancer via the TGF-beta/Smad/C-E-Cad/PI3K/AKT pathway.

Journal: Mol Carcinog
Published: 2022/12/2
PubMed ID: 36453704