circRNA basic information
circBase ID: -
Name: hsa_circ_ITCH
Synonym: circITCH
Host Gene: hsa-miR-20b-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: Huh7, MHCC97, HEK293
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: PTEN
Associated microRNA: hsa-miR-20b-5p
Biological function: sorafenib-sensitivity
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 5
Description:

circITCH enhances sorafenib-sensitivity in sorafenib-resistant HCC cells via regulating the miR-20b-5p/PTEN/PI3K/Akt signaling cascade.
Other information
Title:

Circular RNA ITCH increases sorafenib-sensitivity in hepatocellular carcinoma via sequestering miR-20b-5p and modulating the downstream PTEN-PI3K/Akt pathway.

Journal: Mol Cell Probes
Published: 2022/11/29
PubMed ID: 36442661