circRNA basic information
circBase ID: hsa_circ_0136474
Name: -
Synonym: Circ_0136474
Host Gene: hsa-miR-140-3p
 
 
 
Disease basic information
DO ID:
 8398
DO name: osteoarthritis
Disease details: osteoarthritis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: CHON-001
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MECP2
Associated microRNA: hsa-miR-140-3p
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 2
Description:

Circ_0136474 knockdown alleviated IL-1beta-triggered CHON-001 cell damage through modulation of miR-140-3p/MECP2 axis, indicating a new target for treatment of OA.
Other information
Title:

Circ_0136474 promotes the progression of osteoarthritis by sponging mir-140-3p and upregulating MECP2.

Journal: J Mol Histol
Published: 2022/11/27
PubMed ID: 36435914