circRNA basic information
circBase ID: -
Name: hsa_circ_TDRD3
Synonym: circTDRD3
Host Gene: -
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: proliferation and metastasis
Molecular mechanism: -
Survival: -
Supported No.:
 1
Description:

circTDRD3 facilitates the proliferation and metastasis of CRC through a positive feedback loop mediated by the HIF1alpha/PTBP1/circTDRD3/miR-1231/HIF1alpha axis. Therefore, circTDRD3 may serve as a prognostic biomarker and therapeutic target for patients with CRC.
Other information
Title:

Novel hypoxia-induced HIF1alpha-circTDRD3-positive feedback loop promotes the growth and metastasis of colorectal cancer.

Journal: Oncogene
Published: 2022/11/24
PubMed ID: 36418471