circRNA basic information
circBase ID: -
Name: hsa_circ_HECTD1
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 10325
DO name: silicosis
Disease details: silicosis
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
DN
Associated gene: HECTD1
Associated microRNA: -
Biological function: mediates silica-induced macrophage activation
Molecular mechanism: circHECTD1 and HECTD1 were involved in SiO(2)-induced macrophage activation via ubiquitination
Survival: -
Supported No.:
 1
Description:

Our study elucidated a link between SiO2-induced macrophage activation and the circHECTD1/HECTD1 pathway, thereby providing new insight into the potential use of HECTD1 in the development of novel therapeutic strategies for treating silicosis.
Other information
Title:

circRNA Mediates Silica-Induced Macrophage Activation Via HECTD1/ZC3H12A-Dependent Ubiquitination.

Journal: Theranostics
Published: 2018/1/2
PubMed ID: 29290828