circRNA basic information
circBase ID: hsa_circ_0043949
Name: hsa_circ_BRCA1
Synonym: circ_0043949
Host Gene: hsa-miR-876-3p
 
 
 
Disease basic information
DO ID:
 3073
DO name: brain glioblastoma multiforme
Disease details: glioblastoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: A172 , U251
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-876-3p
Biological function: TMZ resistance
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 2
Description:

TMZ-resistant GBM cells-derived exosomal circ_0043949 promoted TMZ resistance via upregulating ITGA1 expression via sequestering miR-876-3p, offering a potential target for the treatment of TMZ resistance in GBM.
Other information
Title:

Hsa_circ_0043949 reinforces temozolomide resistance via upregulating oncogene ITGA1 axis in glioblastoma.

Journal: Metab Brain Dis
Published: 2022/10/28
PubMed ID: 36301458