circRNA basic information
circBase ID: hsa_circ_0000284
Name: hsa_circ_HIPK3
Synonym: -
Host Gene: hsa-miR-330-5p
 
 
 
Disease basic information
DO ID:
 1793
DO name: pancreatic cancer
Disease details: pancreatic cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human PC cell lines (PANC-1, SW 1990)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: RASSF1
Associated microRNA: hsa-miR-330-5p
Biological function: Promotes Gemcitabine (GEM) Resistance
Molecular mechanism: Sponging hsa-miR-330-5p and Targets RASSF1
Survival: -
Supported No.:
 2
Description:

CircHIPK3 promotes gemcitabine (GEM) resistance in pancreatic cancer cells by targeting RASSF1 via miR-330-5p and regulates proliferation, invasive, migration, EMT, and apoptosis. Our research revealed that circHIPK3 may be a novel biomarker in GEM-resistant PC and could be used as a prognostic target.
Other information
Title:

CircHIPK3 Promotes Gemcitabine (GEM) Resistance in Pancreatic Cancer Cells by Sponging miR-330-5p and Targets RASSF1.

Journal: Cancer Manag Res
Published: 2020/2/28
PubMed ID: 32104074