circRNA basic information
circBase ID: -
Name: hsa_circ_FKBP5
Synonym: circFKBP5
Host Gene: hsa-miR-708-5p
 
 
 
Disease basic information
DO ID:
 11121
DO name: pulpitis
Disease details: pulpitis
Species: human
Species details: human
Sample type: cell line
Sample type details: human DPSC
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: GIT2
Associated microRNA: hsa-miR-708-5p
Biological function: reexpression of circFKBP5 attenuated LPS-induced apoptosis, inflammation, and inhibition of proliferation ability and osteogenic differentiation in hDPSCs.
Molecular mechanism: circFKBP5 acted as a sponge for miR-708-5p, which was verified to target GIT2. LPS induced miR-708-5p expression in hDPSCs, and knockdown of miR-708-5p protected against LPS-evoked hDPSC dysfunction.
Survival: -
Supported No.:
 1
Description:

CircFKBP5 could protect against LPS-induced apoptosis, inflammation, and osteogenic differentiation inhibition in hDPSCs via the miR-708-5p/GIT2 axis.
Other information
Title:

CircFKBP5 Suppresses Apoptosis and Inflammation and Promotes Osteogenic Differentiation.

Journal: Int Dent J
Published: 2022/10/17
PubMed ID: 36244799