circRNA basic information
circBase ID: hsa_circ_0000851
Name: hsa_circ_TCF4
Synonym: circ_0000851
Host Gene: hsa-miR-1183
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human epithelial breast cell line (MCF-10A), human BC cell lines (MDA-MB-231, BT-549, MDA-MB-468, MCF-7)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PDK1
Associated microRNA: hsa-miR-1183
Biological function: proliferation and migration
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

hsa_circ_0000851 bound directly to miR-1183, accelerating the expression of its target gene PDK1, which facilities BC cell proliferation and migration through PDK1/p-AKT.
Other information
Title:

Hsa_circ_0000851 promotes PDK1/p-AKT-mediated cell proliferation and migration by regulating miR-1183 in triple-negative breast cancer.

Journal: Cell Signal
Published: 2022/10/15
PubMed ID: 36241055