circRNA basic information
circBase ID: hsa_circ_0092306
Name: hsa_circ_CCS
Synonym: Circ-CCS
Host Gene: hsa-miR-197-3p
 
 
 
Disease basic information
DO ID:
 9253
DO name: gastrointestinal stromal tumor
Disease details: gastrointestinal stromal tumour
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ATG10
Associated microRNA: hsa-miR-197-3p
Biological function: imatinib resistance
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

By modulating the miR-197-3p/ATG10 axis, circ-CCS increased imatinib resistance in GIST cells, establishing a potential target for reversing medication resistance in such patients.
Other information
Title:

Circ-CCS enhances autophagy during imatinib resistance of gastrointestinal stromal tumor by regulating miR-197-3p/ATG10 signaling.

Journal: J Cancer Res Ther
Published: 2022/10/8
PubMed ID: 36204881