circRNA basic information
circBase ID: -
Name: hsa_circ_LIFR
Synonym: circLIFR
Host Gene: -
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
S
Detected method confidence Low
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: cell proliferation, migration, and invasion
Molecular mechanism: NF-kappaB pathway
Survival: -
Supported No.:
 2
Description:

the downregulation of circLIFR in HCC has a can-cer-promoting effect by interacting with TBK1 to promote the activation of downstream NF-kappaB pathway genes related to cell proliferation, migration, and invasion.
Other information
Title:

Downregulation of circLIFR exerts cancer-promoting effects on hepatocellular carcinoma in vitro.

Journal: Front Genet
Published: 2022/10/1
PubMed ID: 36176304