circRNA basic information
circBase ID: -
Name: hsa_circ_PAK1
Synonym: CircPAK1
Host Gene: -
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Survival: poor
Supported No.:
 1
Description:

CircPAK1 exerts its oncogenic function by competitively binding 14-3-3 zeta with YAP, thus promoting YAP nucleus localization, leading to the inactivation of a Hippo signaling pathway.
Other information
Title:

CircPAK1 promotes the progression of hepatocellular carcinoma via modulation of YAP nucleus localization by interacting with 14-3-3zeta.

Journal: J Exp Clin Cancer Res
Published: 2022/9/22
PubMed ID: 36131287