circRNA basic information
circBase ID: -
Name: hsa_circ_ZNF644
Synonym: circ-ZNF644
Host Gene: hsa-miR-335-5p
 
 
 
Disease basic information
DO ID:
 3021
DO name: acute kidney failure
Disease details: acute kidney injury
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: kidney tubular epithelial cell (HK2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HIPK1
Associated microRNA: hsa-miR-335-5p
Biological function: Circ-ZNF644 knockdown suppressed LPS-induced HK2 cell injury, and this effect could be revoked by miR-335-5p inhibitor.
Molecular mechanism: MiR-335-5p was sponged by circ-ZNF644, and its expression was downregulated in sepsis-induced AKI patients. HIPK1 was targeted by miR-335-5p, and its expression could be suppressed by circ-ZNF644 knockdown.
Survival: -
Supported No.:
 2
Description:

Circ-ZNF644 knockdown relieved LPS-induced HK2 cell injury through the miR-335-5p/HIPK1 axis, confirming that circ-ZNF644 contributed to sepsis-induced AKI.
Other information
Title:

Downregulation of circ-ZNF644 alleviates LPS-induced HK2 cell injury via miR-335-5p/HIPK1 axis.

Journal: Environ Toxicol
Published: 2022/9/3
PubMed ID: 36052886