circRNA basic information
circBase ID: -
Name: hsa_circ_SCAPER
Synonym: CircSCAPER
Host Gene: hsa-miR-127-5p
 
 
 
Disease basic information
DO ID:
 8398
DO name: osteoarthritis
Disease details: osteoarthritis
Species: human
Species details: human
Sample type: cell line
Sample type details: CHON-001
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TLR4
Associated microRNA: hsa-miR-127-5p
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

CircSCAPER silencing protected against IL-1beta-induced apoptosis, ECM degradation, inflammation and oxidative stress in chondrocytes via miR-127-5p/TLR4 axis.
Other information
Title:

CircSCAPER knockdown attenuates IL-1beta-induced chondrocyte injury by miR-127-5p/TLR4 axis in osteoarthritis.

Journal: Autoimmunity
Published: 2022/8/23
PubMed ID: 35993243