circRNA basic information
circBase ID: -
Name: hsa_circ_METTL3
Synonym: circMETTL3
Host Gene: hsa-miR-107
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HCT116, HCT15, LoVo, SW480, SW620, Caco-2
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: PER3
Associated microRNA: hsa-miR-107
Biological function: metastasis
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 4
Description:

CircMETTL3, transcriptionally activated by RUNX3, restrains CRC development and metastasis via acting as a miR-107 sponge to regulate PER3 signaling.
Other information
Title:

RUNX3-regulated circRNA METTL3 inhibits colorectal cancer proliferation and metastasis via miR-107/PER3 axis.

Journal: Cell Death Dis
Published: 2022/6/18
PubMed ID: 35710754