circRNA basic information
circBase ID: -
Name: hsa_circ_safb2
Synonym: Circsafb2
Host Gene: hsa-miR-620
 
 
 
Disease basic information
DO ID:
 4450
DO name: renal cell carcinoma
Disease details: renal cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: A498, 786-O, Caki1, Caki2, 769-P, ACHN
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: STAT3
Associated microRNA: hsa-miR-620
Biological function: M2 macrophage polarization
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

circSAFB2 leads to immune escape from RCC by mediating M2 macrophage polarization via the miR-620/JAK1/STAT3 axis.
Other information
Title:

Exosomal Circsafb2 Reshaping Tumor Environment to Promote Renal Cell Carcinoma Progression by Mediating M2 Macrophage Polarization.

Journal: Front Oncol
Published: 2022/6/2
PubMed ID: 35646637