circRNA basic information
circBase ID: -
Name: hsa_circ_LHFPL2
Synonym: circLHFPL2
Host Gene: hsa-miR-556-5p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HCT116£» DLD1
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-556-5p
Biological function: -
Molecular mechanism: PI3K/AKT signaling pathway
Survival: -
Supported No.:
 1
Description:

Downregulation of circLHFPL2 sustains the activation of the PI3K/AKT signaling pathway via a positive feedback loop in PIK3CA-mutant CRC.
Other information
Title:

PIK3CA mutations-mediated downregulation of circLHFPL2 inhibits colorectal cancer progression via upregulating PTEN.

Journal: Mol Cancer
Published: 2022/5/27
PubMed ID: 35619132