circRNA basic information
circBase ID: hsa_circ_0000291
Name: -
Synonym: Circ_0000291
Host Gene: hsa-miR-1322
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HCC cell lines (Huh-7, LM3, LM6, MHCC97H), human normal cell line (THLE-2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1322
Biological function: circ_0000291 knockdown restrained the proliferation, migration, invasion, and stemness and induced the apoptosis of HCC cells.
Molecular mechanism: Circ_0000291 directly interacted with hsa-miR-1322 and negatively regulated hsa-miR-1322 expression. hsa-miR-1322 directly paired with the 3 untranslated region (3UTR) of UBE2T, and UBE2T was negatively regulated by hsa-miR-1322.
Survival: poor
Supported No.:
 1
Description:

Circ_0000291 facilitated HCC progression by targeting miR-1322/UBE2T axis, which provided novel potential biomarkers and targets for HCC patients.
Other information
Title:

Circ_0000291 contributes to hepatocellular carcinoma tumorigenesis by binding to miR-1322 to up-regulate UBE2T.

Journal: Ann Hepatol
Published: 2022/5/16
PubMed ID: 35569812