circRNA basic information
circBase ID: -
Name: hsa_circ_EIF3H
Synonym: CircEIF3H
Host Gene: -
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human breast cancer cells (MDA-MB-231, MDA-MB-468, MDA-MB-453), 293_T
circRNA-disease information
Detected method:
S
Detected method confidence Low
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: circEIF3H was essential for TNBC proliferation and metastasis.
Molecular mechanism: circEIF3H did not function as a microRNA sponge as in the most well-established pathway, but as a scaffold for IGF2BP2 and HuR to regulate the mRNA stability of HSPD1, RBM8A, and G3BP1.
Survival: -
Supported No.:
 1
Description:

Our findings provide insight into a novel circRNA, circEIF3H, with significant cancer-promoting function via serving as a scaffold for IGF2BP2/HuR. These results identified circEIF3H as a potential target for developing individualized therapy of TNBC in the approaching future.
Other information
Title:

CircEIF3H-IGF2BP2-HuR scaffold complex promotes TNBC progression via stabilizing HSPD1/RBM8A/G3BP1 mRNA.

Journal: Cell Death Discov
Published: 2022/5/15
PubMed ID: 35568705