circRNA basic information
circBase ID: hsa_circ_0000615
Name: hsa_circ_ZNF609
Synonym: CircZNF609
Host Gene: hsa-miR-1200
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: T24, BIU87 BCa cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1200
Biological function: In vitro and in vivo, enforced expression of circZNF609 enhanced BCa cells proliferation, migration, and cisplatin chemoresistance.
Molecular mechanism: Mechanistically, circZNF609 alleviated the inhibition effect on target CDC25B expression by sponging hsa-miR-1200. CircZNF609 promoted tumor growth through novel circZNF609/hsa-miR-1200/CDC25B axis
Survival: poor
Supported No.:
 1
Description:

This research reveals that circZNF609 improves bladder cancer progression and inhibits cisplatin sensitivity by inducing G1/S cell cycle arrest via a novel miR-1200/CDC25B cascades. 2. CircZNF609 was confirmed associated with worse survival of bladder cancer patients. 3. CircZNF609 act as a prognostic biomarker for bladder cancer treatment.
Other information
Title:

CircZNF609 promotes bladder cancer progression and inhibits cisplatin sensitivity via miR-1200/CDC25B pathway.

Journal: Cell Biol Toxicol
Published: 2022/5/15
PubMed ID: 35567596