circRNA basic information
circBase ID: hsa_circ_0120376
Name: -
Synonym: circ_0120376
Host Gene: hsa-miR-148b-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: NSCLC cell lines (A549, H596, H2087, H520), immortalized lung epithelial cell line (16HBE)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-148b-3p
Biological function: Functional experiments unveiled that circ_0120376 enhanced the proliferation, migration and invasion of NSCLC cells and impeded apoptosis, while knocking down circ_0120376 remarkably suppressed the malignant features of NSCLC cells mentioned above.
Molecular mechanism: Circ_0120376 could adsorb hsa-miR-148b-3p to reduce hsa-miR-148b-3p expression, and circ_0120376 could increase CEP55 expression via adsorbing hsa-miR-148b-3p.
Survival: -
Supported No.:
 1
Description:

In summary, circ_0120376 contributes to the malignancy of NSCLC cells through a ceRNA mechanism via regulating miR-148b-3p/CEP55 axis. Circ_0120376 is likely to be a potential diagnostic biomarker and therapeutic target for NSCLC.
Other information
Title:

Circular RNA_0120376 regulates microRNA-148b-3 and centrosomal protein 55 to promote non-small cell lung cancer development.

Journal: Bioengineered
Published: 2022/5/14
PubMed ID: 35549631