circRNA basic information
circBase ID: -
Name: -
Synonym: circ008913
Host Gene: hsa-miR-889
 
 
 
Disease basic information
DO ID:
 162
DO name: cancer
Disease details: cancer
Species: human
Species details: human
Sample type: cell line
Sample type details: HaCaT
circRNA-disease information
Detected method:
S
Detected method confidence Low
Expression pattern:
DN
Associated gene: DAB2IP, ZEB1
Associated microRNA: hsa-miR-889
Biological function: -
Molecular mechanism: via hsa-miR-889 regulation of DAB2IP/ZEB1
Survival: -
Supported No.:
 1
Description:

These results suggest that, in HaCaT cells, arsenite decreases circ008913 levels, which act as a sponge for miR-889 and down-regulate the miR-889 target, DAB2IP, which, in turn, up-regulates ZEB1, increases mRNA levels of the cell-surface markers of skin stem cells, and is involved in arsenite-induced acquisition of CSC-like properties that lead to malignant transformation.
Other information
Title:

Circ008913, via miR-889 regulation of DAB2IP/ZEB1, is involved in the arsenite-induced acquisition of CSC-like properties by human keratinocytes in carcinogenesis.

Journal: Metallomics
Published: 2018/9/1
PubMed ID: 30167605