circRNA basic information
circBase ID: hsa_circ_0000345
Name: hsa_circ_RSF1
Synonym: circ_0000345
Host Gene: hsa-miR-513a-3p
 
 
 
Disease basic information
DO ID:
 9261
DO name: nasopharynx carcinoma
Disease details: nasopharyngeal carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal nasopharynx epithelial cells (NP69), NPC cell lines (SUNE1, HONE1, 6-10B, HNE1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: PTEN
Associated microRNA: hsa-miR-513a-3p
Biological function: hsa_circ_0000345 overexpression repressed cell proliferation, migration and invasion of SUNE1 cells, whereas hsa_circ_0000345 knockdown promoted cell proliferation, migration and invasion of 6-10B cells.
Molecular mechanism: hsa_circ_0000345 promoted PTEN expression by sponging hsa-miR-513a-3p. Both hsa-miR-513a-3p overexpression and PTEN knockdown promoted cell proliferation, migration and invasion of SUNE1 cells, which were effectively abolished by hsa_circ_0000345 up-regulation.
Survival: -
Supported No.:
 1
Description:

Hsa_circ_0000345 inhibits cell proliferation, migration and invasion of NPC cells via miR-513a-3p/PTEN axis, thereby suppressing the progression of NPC. Thus, this work suggests that hsa_circ_0000345 may be a potential biomarker for diagnosis and treatment of NPC.
Other information
Title:

Hsa_circ_0000345 inhibits cell proliferation, migration and invasion of nasopharyngeal carcinoma cells via miR-513a-3p/PTEN axis.

Journal: J Physiol Sci
Published: 2022/5/12
PubMed ID: 35545766