circRNA basic information
circBase ID: hsa_circ_0000285
Name: hsa_circ_HIPK3
Synonym: circ_0000285
Host Gene: hsa-miR-1278
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: HGC_27, AGS, GTL_16 cell lines, human gastric epithelial cell line (GES_1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1278
Biological function: Silencing hsa_circ_0000285 inhibited cell proliferation and invasion, promoted apoptosis, and inhibited tumor development.
Molecular mechanism: Hsa_circ_0000285 sponged hsa-miR-1278. Inhibition of hsa-miR-1278 in vitro reversed the effects of hsa_circ_0000285 silencing on GC progression. hsa-miR-1278 targeted FN1, and silencing FN1 neutralized the effects of hsa-miR-1278 inhibitors on GC progression.
Survival: -
Supported No.:
 6
Description:

The hsa_circ_0000285/miR-1278/FN1 axis regulated GC progression. In addition, it may serve as a potential therapeutic biomarker for GC.
Other information
Title:

Hsa_circ_0000285 contributes to gastric cancer progression by upregulating FN1 through the inhibition of miR-1278.

Journal: J Clin Lab Anal
Published: 2022/5/11
PubMed ID: 35535385