circRNA basic information
circBase ID: -
Name: hsa_circ_ZNF609
Synonym: circZNF609
Host Gene: -
 
 
 
Disease basic information
DO ID:
 1909
DO name: melanoma
Disease details: melanoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: A2058, A375, A875, G361, LOX-IMVI, M14, SK-MEL-1, SK-MEL-2, SK-MEL-5, SK-MEL-28, WM115, WM2664, DEOC-1, HMY-1, LM-MEL-45
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: circZNF609 inhibited metastasis of acral and cutaneous melanoma in vivo and in vitro.
Molecular mechanism: circZNF609 promoted the binding of FMRP protein and RAC1 mRNA, thereby enhancing the inhibitory effect of FMRP protein on the stability of RAC1 mRNA and ultimately inhibiting melanoma metastasis.
Survival: -
Supported No.:
 1
Description:

Our findings revealed that circZNF609 plays a vital role in the metastasis of acral and cutaneous melanoma through the circRNF609-FMRP-RAC1 axis and indicated that circZNF609 regulates the stability of RAC1 mRNA by combining with FMRP, which might provide insight into melanoma pathogenesis and a new potential target for treatment of melanoma.
Other information
Title:

FMRP ligand circZNF609 destabilizes RAC1 mRNA to reduce metastasis in acral melanoma and cutaneous melanoma.

Journal: J Exp Clin Cancer Res
Published: 2022/5/10
PubMed ID: 35534866