circRNA basic information
circBase ID: hsa_circ_0003159
Name: hsa_circ_CACNA2D1
Synonym: circ_0003159
Host Gene: hsa-miR-223-3p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human gastric mucosal epithelial cells (GES-1), GC cell lines (SGC7901, BGC-823, MKN-7, HGC-27, NUGC-3, AGS, HS-746T, N87)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-223-3p
Biological function: hsa_circ_0003159 was downregulated in GC cell lines and its overexpression promoted GC cell viability.
Molecular mechanism: hsa-miR-223-3p was identified as a target of hsa_circ_0003159. By competitively sponging hsa-miR-223-3p, hsa_circ_0003159 positively regulated NLRP3 expression.
Survival: -
Supported No.:
 3
Description:

In conclusion, this study indicated ICA inhibits GC cell growth by regulating the hsa_circ_0003159/miR-223-3p/NLRP3 signaling axis. This study not only reveals the mechanism of gastric carcinogenesis but also provides potential molecular targets and therapeutic tools for its treatment.
Other information
Title:

Icariin inhibits gastric cancer cell growth by regulating the hsa_circ_0003159/miR-223-3p/NLRP3 signaling axis.

Journal: Hum Exp Toxicol
Published: 2022/5/10
PubMed ID: 35532261