circRNA basic information
circBase ID: hsa_circ_0000523
Name: hsa_circ_METTL3
Synonym: circ_0000523
Host Gene: hsa-let-7b
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human CRC cell line (HCT116)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-let-7b
Biological function: miR-let-7b_romoted cell viability and inhibited apoptosis and invasion, while_irc_0000523_xerted the opposite effects.
Molecular mechanism: hsa_circ_0000523_ndirectly regulated_ETTL3_xpression by suppressing the transcription of microRNA (miR)-let-7b.
Survival: -
Supported No.:
 4
Description:

The present results suggest that circRNAs and_ETTL3_ay be applied for highly sensitive diagnosis of CRC and for predicting prognosis in patients who have undergone therapy.
Other information
Title:

hsa_circ_0000523/miR-let-7b/METTL3 axis regulates proliferation, apoptosis and metastasis in the HCT116 human colorectal cancer cell line.

Journal: Oncol Lett
Published: 2022/5/10
PubMed ID: 35527788