circRNA basic information
circBase ID: -
Name: hsa_circ_HMGB2
Synonym: circHMGB2
Host Gene: hsa-miR-181a-5p
 
 
 
Disease basic information
DO ID:
 1324
DO name: lung cancer
Disease details: lung adenocarcinomas (LUAD) and squamous cell carcinomas (LUSC).
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human NSCLC cell lines (A549, PC-9, NCI-H460, NCI-H1299, NCI-H1703), human bronchial epithelial (HBE) cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-181a-5p
Biological function: circHMGB2 exerted a mild effect on the proliferation of the LUAD and LUSC cells, but circHMGB2 substantially reshaped the tumor microenvironment by contributing to the exhaustion of antitumor immunity in an immunocompetent mouse model and a humanized mouse model.
Molecular mechanism: circHMGB2 relieves the inhibition of downstream CARM1 by sponging hsa-miR-181a-5p, thus inactivating the type 1 interferon response in the LUAD and LUSC.
Survival: -
Supported No.:
 1
Description:

circHMGB2 overexpression promotes the LUAD and LUSC progression mainly by reshaping the tumor microenvironment and regulating anti-PD-1 resistance in the LUAD and LUSC patients. This study provides a new strategy for the LUAD and LUSC treatment.
Other information
Title:

The circular RNA circHMGB2 drives immunosuppression and anti-PD-1 resistance in lung adenocarcinomas and squamous cell carcinomas via the miR-181a-5p/CARM1 axis.

Journal: Mol Cancer
Published: 2022/5/8
PubMed ID: 35525959