circRNA basic information
circBase ID: hsa_circ_0054595
Name: hsa_circ_RTN4
Synonym: CircRTN4
Host Gene: hsa-miR-513a-5p
 
 
 
Disease basic information
DO ID:
 0080162
DO name: lupus nephritis
Disease details: lupus nephritis
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human renal mesangial cells (HRMCs)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: FN
Associated microRNA: hsa-miR-513a-5p
Biological function: High circRTN4 expression in monocytes disseminated into HRMCs in an exosomal manner, thereby accelerating cell proliferation and extracellular matrix deposition.
Molecular mechanism: circRTN4 could enhance FN expression by directly interacting with hsa-miR-513a-5p.
Survival: -
Supported No.:
 1
Description:

Our findings indicated that circRTN4 exacerbates mesangial cell dysfunction by activating the miR-513a-5p/FN axis in lupus nephritis.
Other information
Title:

CircRTN4 aggravates mesangial cell dysfunction by activating the miR-513a-5p/FN axis in lupus nephritis.

Journal: Lab Invest
Published: 2022/5/7
PubMed ID: 35523949