circRNA basic information
circBase ID: -
Name: hsa_circ_SPECC1
Synonym: circSPECC1
Host Gene: hsa-miR-136-5p
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: Bca cells (5637, J82, T24, SW780) ,SV-HUC1 cell
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-136-5p
Biological function: Further tests showed that knockdown of circSPECC1 impaired the proliferation and migration of Bca cells.
Molecular mechanism: circSPECC1 sponged hsa-miR-136-5p to promote the mRNA and protein expression of GNAS.
Survival: poor
Supported No.:
 1
Description:

In general, our study suggested that circSPECC1 contributed to the growth and metastasis of Bca and it is possible to become an ideal non-invasive biomarker for diagnosis and effective therapeutic target for treatment.
Other information
Title:

circSPECC1 promotes bladder cancer progression via regulating miR-136-5p/GNAS axis.

Journal: Pathol Res Pract
Published: 2022/5/7
PubMed ID: 35523104