circRNA basic information
circBase ID: hsa_circ_0023984
Name: hsa_circ_NOX4
Synonym: circ_0023984
Host Gene: hsa-miR-1294
 
 
 
Disease basic information
DO ID:
 1749
DO name: squamous cell carcinoma
Disease details: squamous cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human ESCC cell lines (KYSE150, TE-1, EC109), an immortalized human esophageal epithelial cell line (Het-1A)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1294
Biological function: circ_0023984 overexpression remarkably enhanced ESCC cell proliferation, migration, invasion, and cell cycle progression, while knockdown of circ_0023984 showed the opposite effect.
Molecular mechanism: circ_0023984 was the molecular sponge of hsa-miR-1294._he target genes of hsa-miR-1294 were associated with cell cycle arrest and PI3K-Akt signaling pathway.
Survival: -
Supported No.:
 1
Description:

circ_0023984 upregulated the expression of p-Akt and c-Myc by repressing miR-1294. circ_0023984 facilitates the malignant biological behaviors of ESCC cells through inhibiting miR-1294 and activating PI3K/Akt/c-myc pathway.
Other information
Title:

Hsa_circ_0023984 Regulates Cell Proliferation, Migration, and Invasion in Esophageal Squamous Cancer via Regulating miR-1294/PI3K/Akt/c-Myc Pathway.

Journal: Appl Biochem Biotechnol
Published: 2022/5/7
PubMed ID: 35522362