circRNA basic information
circBase ID: hsa_circ_0015004
Name: hsa_circ_SDHC
Synonym: circSDHC
Host Gene: hsa-miR-130a-3p
 
 
 
Disease basic information
DO ID:
 4450
DO name: renal cell carcinoma
Disease details: renal cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: RCC cell lines (A498, 786-O), immortalized proximal tubule cell line (HK2), human umbilical vein endothelial cell line (HUVEC)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-130a-3p
Biological function: circSDHC silencing decreased xenograft tumor growth and induced RCC cell apoptosis, repressed RCC cell proliferation, angiogenesis, migration, and invasion in vitro.
Molecular mechanism: circSDHC modulated centrosomal protein 55 (CEP55) expression by functioning as a hsa-miR-130a-3p sponge. Also, hsa-miR-130a-3p silencing offset circSDHC knockdown-mediated impacts on malignant phenotypes and angiogenesis of RCC cells. Furthermore, exogenetic expression of CEP55 counteracted hsa-miR-130a-3p overexpression-mediated effects on malignant phenotypes and angiogenesis of RCC cells.
Survival: -
Supported No.:
 1
Description:

Silencing of circSDHC restrained cell malignant phenotypes and angiogenesis via reducing CEP55 expression by releasing miR-130a-3p in RCC, providing a new mechanism for understanding the progression of RCC.
Other information
Title:

Circular RNA circSDHC (hsa_circ_0015004) regulates tumor growth and angiogenesis via regulating centrosomal protein 55 expression in renal cell carcinoma.

Journal: Histol Histopathol
Published: 2022/5/5
PubMed ID: 35506422