circRNA basic information
circBase ID: -
Name: hsa_circ_VPRBP
Synonym: circ_VPRBP
Host Gene: hsa-miR-93-5p
 
 
 
Disease basic information
DO ID:
 4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: Caski, C33A cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-93-5p
Biological function: overexpression of circ_VPRBP inhibited proliferation and promoted apoptosis of Caski and C33A cells.
Molecular mechanism: hsa-miR-93-5p was a target of circ_VPRBP, and hsa-miR-93-5p mimic reversed the effect of circ_VPRBP on cell behavior. FRMD6 was a downstream target of hsa-miR-93-5p, and down-regulated FRMD6 reversed the cell viability, migration and invasion of cervical cancer cells inhibited by anti-hsa-miR-93-5p. Circ_VPRBP inhibited tumor growth by regulating hsa-miR-93-5p and FRMD6 in vivo.
Survival: -
Supported No.:
 4
Description:

Circ_VPRBP inhibited cell proliferation, migration and invasion and promoted cell apoptosis of cervical cancer cells by regulating miR-93-5p/FRMD6 axis.
Other information
Title:

CircRNA VPRBP inhibits tumorigenicity of cervical cancer via miR-93-5p/FRMD6 axis.

Journal: Reprod Sci
Published: 2022/5/3
PubMed ID: 35501594