circRNA basic information
circBase ID: -
Name: hsa_circ_HIPK3
Synonym: CircHIPK3
Host Gene: hsa-miR-382-5p
 
 
 
Disease basic information
DO ID:
 319
DO name: spinal cord disease
Disease details: spinal cord injury
Species: human
Species details: human
Sample type: cell line
Sample type details: OGD-induced AGE1.HN cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-382-5p
Biological function: Overexpression of circHIPK3 suppressed inflammatory response and cell apoptosis and promoted proliferation in OGD-induced AGE1.
Molecular mechanism: CircHIPK3 regulated DUSP1 expression by targeting hsa-miR-382-5p. hsa-miR-382-5p inhibition hindered inflammatory response of IL-6 and TNF-alpha and neuronal apoptosis and promoted apoptosis via targeting DUSP1.
Survival: -
Supported No.:
 2
Description:

CircHIPK3 overexpression alleviated OGD-induced AGE1.HN cell inflammatory response and neuronal apoptosis via regulating miR-382-5p/DUSP1 axis, indicating that circHIPK3 might be a promising therapeutic target for SCI.
Other information
Title:

CircHIPK3 alleviates inflammatory response and neuronal apoptosis via regulating miR-382-5p/DUSP1 axis in spinal cord injury.

Journal: Transpl Immunol
Published: 2022/5/3
PubMed ID: 35500847