circRNA basic information
circBase ID: hsa_circ_0004396
Name: hsa_circ_HUWE1
Synonym: -
Host Gene: hsa-miR-615-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: A549, SPC_A1, BEAS_2B, HEK293T cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-615-5p
Biological function: Hsa_circ_0004396 silencing inhibited NSCLC cell malignant behavior and induced radiosensitivity._oreover, hsa_circ_0004396 knockdown inhibited NSCLC tumor growth in vivo.
Molecular mechanism: sa_circ_0004396 functions as a molecular sponge of hsa-miR-615-5p to regulate PAK1 expression.
Survival: -
Supported No.:
 2
Description:

Our findings demonstrated that hsa_circ_0004396 promoted NSCLC development and radioresistance through the miR-615-5p/PAK1 axis, which might provide a new therapeutic target for NSCLC treatment.
Other information
Title:

Circular RNA hsa_circ_0004396 acts as a sponge of miR-615-5p to promote non-small cell lung cancer progression and radioresistance through the upregulation of P21-Activated Kinase 1.

Journal: J Clin Lab Anal
Published: 2022/5/3
PubMed ID: 35500159