circRNA basic information
circBase ID: hsa_circ_0003528
Name: hsa_circ_SEC24A
Synonym: circ_0003528
Host Gene: hsa-miR-212-3p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: HCC cell lines (HepG2, HUH7), normal hepatocytes (THLE-2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-212-3p
Biological function: Knockdown of circ_0003528 suppressed the aggressiveness of HCC cells and tumor growth both_n vitro_nd_n vivo.
Molecular mechanism: binding of hsa-miR-212-3p to circ_0003528 and_IAP_as verified._ownregulation of hsa-miR-212-3p abrogated the effects of si-circ_0003528 on cell viability and apoptosis, and upregulation of XIAP antagonized the functions of the hsa-miR-212-3p mimic in HCC cells.
Survival: -
Supported No.:
 4
Description:

circ_0003528 contributes to the development of HCC_n vitro_nd_n vivo_ia the miR-212-3p/XIAP_xis. Hence, circ_0003528 knockdown may be a potential therapeutic strategy for HCC treatment.
Other information
Title:

Down-regulated HSA_circ_0003528 inhibits hepatocellular carcinoma aggressiveness via the miR-212-3p/XIAP axis.

Journal: Bioengineered
Published: 2022/4/30
PubMed ID: 35484994