circRNA basic information
circBase ID: -
Name: hsa_circ_OXCT1
Synonym: circ-OXCT1
Host Gene: hsa-miR-516b-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: NSCLC cell lines (A549, H1975, H1650), control cell line (16HBE)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-516b-5p
Biological function: circ-OXCT1 silencing suppressed cell proliferation, migration and invasion, but promoted cell apoptosis_n vitro. Circ-OXCT1 knockdown repressed tumor formation_n vivo.
Molecular mechanism: hsa-miR-516b-5p was a target of circ-OXCT1, and hsa-miR-516b-5p inhibitor could relieve circ-OXCT1 absence-mediated effects in NSCLC cells. SLC1A5 was identified as a target of hsa-miR-516b-5p. Circ-OXCT1 promoted SLC1A5 expression by target binding with hsa-miR-516b-5p.
Survival: -
Supported No.:
 1
Description:

Circ-OXCT1 facilitated NSCLC progression via miR-516b-5p-dependent regulation of SLC1A5, which provided a possible circRNA-targeted therapy for NSCLC.
Other information
Title:

CircRNA OXCT1 promotes the malignant progression and glutamine metabolism of non-small cell lung cancer by absorbing miR-516b-5p and upregulating SLC1A5.

Journal: Cell Cycle
Published: 2022/4/29
PubMed ID: 35482822