circRNA basic information
circBase ID: -
Name: hsa_circ_NNT
Synonym: circ_NNT
Host Gene: hsa-miR-320b
 
 
 
Disease basic information
DO ID:
 8947
DO name: diabetic retinopathy
Disease details: Diabetic retinopathy
Species: human
Species details: human
Sample type: cell line
Sample type details: Human retinal pigment epithelial cells ARPE-19
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: TIMP3
Associated microRNA: hsa-miR-320b
Biological function: circ_NNT up-regulation reversed HG-evoked apoptosis and inflammation in ARPE-19 cells.
Molecular mechanism: circ_NNT acted as a sponge for miR-320b to elevate TIMP3 expression
Survival: -
Supported No.:
 2
Description:

Circ_NNT protected ARPE-19 cells against HG-evoked apoptosis and inflammation via elevating TIMP3 through sequestering miR-320b, indicating that up-regulation of circ_NNT might contribute to the inhibition of DR process.
Other information
Title:

Circ_NNT suppresses the apoptosis and inflammation in glucose-induced human retinal pigment epithelium by regulating miR-320b/TIMP3 axis in diabetic retinopathy.

Journal: Clin Immunol
Published: 2022/4/28
PubMed ID: 35477026