circRNA basic information
circBase ID: hsa_circ_0039929
Name: hsa_circ_NFATC3
Synonym: circ_0039929
Host Gene: hsa-miR-15b-3p
 
 
 
Disease basic information
DO ID:
 850
DO name: lung disease
Disease details: Inflammation
Species: human
Species details: human
Sample type: cell line
Sample type details: A549 cells
circRNA-disease information
Detected method:
S
Detected method confidence Low
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-15b-3p
Biological function: Upregulated the expressions of hsa_circ_0039929 and FGF2, down-regulated hsa-miR-15b-3p_R-1, activated the PI3K/AKT pathway and promoted EMT.
Molecular mechanism: knockdown of hsa_circ_0039929 could promote the levels of hsa-miR-15b-3p_R-1, while inhibit the expression of FGF2.
Survival: -
Supported No.:
 1
Description:

All above suggested that ceRNA hsa_circ_0039929/hsa-miR-15b-3p_R-1/FGF2 played an important role in the inflammation and EMT caused by LMW-PAHs.
Other information
Title:

The effect of low molecular weight-polycyclic aromatic hydrocarbons responsive hsa_circ_0039929/hsa-miR-15b-3p_R-1/FGF2 circuit on inflammatory response of A549 cells via the PI3K/AKT pathway and epithelial-mesenchymal transition process.

Journal: Environ Toxicol
Published: 2022/4/28
PubMed ID: 35475590