circRNA basic information
circBase ID: hsa_circ_0000658
Name: hsa_circ_MCTP2
Synonym: CircMCTP2
Host Gene: hsa-miR-498
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: J82, T24
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-498
Biological function: CircMCTP2 deficiency impaired the cell growth, migration as well as invasive ability of BC cell lines (J82 and T24)._n vivo, circMCTP2 deficiency cut the tumor growth rates and the tumor weight. In BC cells, circMCTP2 deficiency enhanced the translation of E-cadherin, while diminishing the translation of N-cadherin, Vimentin, and Snail.
Molecular mechanism: circMCTP2 acted as a sponge of hsa-miR-498 to regulate murine double minute-2 (MDM2) expression. In BC tissues, a negative correlation was observed between the expression levels of circMCTP2 and hsa-miR-498. Additionally, either hsa-miR-498 silencing or MDM2 over-expression augmented the carcinogenic action of circMCTP2 on BC.
Survival: poor
Supported No.:
 2
Description:

In conclusion, our study showed that circMCTP2 regulates the expression of MDM2 by sponging miR-498 to promote the development of BC. These findings offer a new strategy for early diagnosis of BC and its therapeutics.
Other information
Title:

CircMCTP2 (has-circ-0000658) facilitates the proliferation and metastasis of bladder carcinoma through modulating the miR-498/murine double minute-2 axis.

Journal: Bioengineered
Published: 2022/4/28
PubMed ID: 35475453