circRNA basic information
circBase ID: hsa_circ_0067934
Name: -
Synonym: circ_0067934
Host Gene: hsa-miR-1301-3p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: cell line
Sample type details: normal gastric mucosal cell line (GES-1), GC cell lines (AGS, MKN-45)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1301-3p
Biological function: circ_0067934 silencing significantly inhibited GC cell proliferation, migration and invasion.
Molecular mechanism: miR_1301_3p was regulated by circ_0067934, and miR_1301_3p overexpression suppressed GC cell migration, invasion and proliferation. miR_1301_3p was found to target KIF23, and KIF23 overexpression reversed the effects of circ_0067934 silencing and miR_1301_3p overexpression on cell proliferation, migration and invasion.
Survival: -
Supported No.:
 3
Description:

In conclusion, circ_0067934 may regulate the proliferation, invasion and migration of GC cells via the miR_1301_3p/KIF23 signaling axis, which may represent a novel therapeutic target for GC metastasis.
Other information
Title:

Knockdown of circ_0067934 inhibits gastric cancer cell proliferation, migration and invasion via the miR_1301_3p/KIF23 axis.

Journal: Mol Med Rep
Published: 2022/4/28
PubMed ID: 35475447