circRNA basic information
circBase ID: -
Name: hsa_circ_MYOF
Synonym: circMYOF
Host Gene: hsa-miR-145-5p
 
 
 
Disease basic information
DO ID:
 2876
DO name: laryngeal squamous cell carcinoma
Disease details: laryngeal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: LSCC cell lines (Tu686, AMC-HN-8, SNU46, Tu177, SNU899), nasopharyngeal epithelial cell line (NP69)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-145-5p
Biological function: Its knockdown suppressed LSCC cell growth, metastasis, and glycolysis, as well as inhibited LSCC tumor growth.
Molecular mechanism: hsa-miR-145-5p had decreased expression in LSCC, and it could be sponged by circMYOF. The inhibition effect of circMYOF lentivirus short hairpin RNA (sh-circMYOF) on LSCC progression was restored by the inhibitor of hsa-miR-145-5p (in-hsa-miR-145-5p). Also, OTX1 was targeted by hsa-miR-145-5p and was positively regulated by circMYOF. hsa-miR-145-5p could repress LSCC progression, and OTX1 overexpression also eliminated this effect.
Survival: -
Supported No.:
 1
Description:

we found that circMYOF was significantly overexpressed in the serum exosomes of LSCC patients. Our data revealed that circMYOF contributed to LSCC progression by promoting cell growth, metastasis, and glycolysis through miR-145-5p/OTX1 axis.
Other information
Title:

Knockdown of circMYOF inhibits cell growth, metastasis, and glycolysis through miR-145-5p/OTX1 regulatory axis in laryngeal squamous cell carcinoma.

Journal: Funct Integr Genomics
Published: 2022/4/28
PubMed ID: 35474406