circRNA basic information
circBase ID: -
Name: hsa_circ_DLC1
Synonym: circDLC1
Host Gene: hsa-miR-671-5p
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human glioma cell lines (T98G, LN229, A172, LN18), healthy glioma cell line (HEB)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-671-5p
Biological function: circDLC1 overexpression suppressed glioma cell proliferation.
Molecular mechanism: METTL3-mediated m6A modification enhanced circDLC1 stability and upregulated circDLC1 expression in glioma. circDLC1 upregulated CTNNBIP1 transcription by competitively binding to hsa-miR-671-5p. METTL3 overexpression repressed the malignant proliferation of glioma via circDLC1/hsa-miR-671-5p/CTNNBIP1 in vivo.
Survival: -
Supported No.:
 1
Description:

Collectively, METTL3-mediated m6A modification upregulated circDLC1 expression, and circDLC1 promoted CTNNBIP1 transcription by sponging miR-671-5p, thus repressing the malignant proliferation of glioma.
Other information
Title:

Molecular mechanism of m(6)A methylation of circDLC1 mediated by RNA methyltransferase METTL3 in the malignant proliferation of glioma cells.

Journal: Cell Death Discov
Published: 2022/4/28
PubMed ID: 35474040