circRNA basic information
circBase ID: hsa_circ_0001875
Name: -
Synonym: circ-0001875
Host Gene: hsa-miR-31-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: NSCLC cell lines (A549, PC9, H838, H1299, 95D), human normal lung epithelial cells (BEAS-2B), 293A cells
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-31-5p
Biological function: circ-0001875 promoted the proliferation and metastasis of NSCLC both in vitro and in vivo, and induced NSCLC cells to extend filopodia.
Molecular mechanism: circ-0001875 sponged hsa-miR-31-5p to regulate SP1, influencing epithelial-to-mesenchymal transition via the TGFbeta/Smad2 signal pathway. SP1 negatively regulated circ-0001875 formation through an AluSq-dependent feedback loop, which was disrupted by competitive binding of HIF1alpha to SP1 under hypoxia condition. The circ-0001875/hsa-miR-31-5p/SP1 axis was associated with the clinical features and prognosis of NSCLC patients.
Survival: -
Supported No.:
 1
Description:

Our results revealed that the circ-0001875/miR-31-5p/SP1 axis and the complex regulatory loops influence NSCLC progression. These findings provide new insights into the regulation of circRNA formation under tumor hypoxia.
Other information
Title:

HIF1alpha-SP1 interaction disrupts the circ-0001875/miR-31-5p/SP1 regulatory loop under a hypoxic microenvironment and promotes non-small cell lung cancer progression.

Journal: J Exp Clin Cancer Res
Published: 2022/4/28
PubMed ID: 35473752