circRNA basic information
circBase ID: hsa_circ_0066436
Name: hsa_circ_ATXN
Synonym: circATXN7
Host Gene: hsa-miR-7-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human tracheobronchial epithelial cells 16HBE, NSCLC cell lines (NCI_H460, NCI_H1299, LK_2, A549)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-7-5p
Biological function: CircATXN7 overexpression constrained apoptosis and promoted proliferation, metastasis, invasion, and epithelial-mesenchymal transition of NSCLC cells, but circATXN7 silencing played the opposing influence and repressed xenograft tumor growth in vivo.
Molecular mechanism: CircATXN7 served as a hsa-miR-7-5p sponge, and circATXN7 regulated malignant behaviors of NSCLC cells through sponging hsa-miR-7-5p. PFN2 acted as a hsa-miR-7-5p target. PFN2 silencing overturned the promoting effect of hsa-miR-7-5p inhibitor on NSCLC cell malignancy, while PFN2 overexpression reversed the inhibitory impact of hsa-miR-7-5p mimic on NSCLC cell malignancy.
Survival: -
Supported No.:
 1
Description:

CircATXN7 accelerated the malignancy of NSCLC cells through adsorbing miR-7-5p and upregulating PFN2, offering evidence to support circATXN7 as a target for NSCLC treatment.
Other information
Title:

Downregulation of circATXN7 represses non-small cell lung cancer growth by releasing miR-7-5p.

Journal: Thorac Cancer
Published: 2022/4/22
PubMed ID: 35445786